Impact of the Hypoxia-Inducible Factor-1 a (HIF-1a) Pro582Ser PolymorphismonDiabetesNephropathy
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چکیده
RESEARCHDESIGNANDMETHODSdIn 1,165 American type 1 diabetic patients with and without DN selected from the Genetics of Kidneys in Diabetes (GoKinD) study, the HIF1A genetic polymorphisms were genotyped with TaqMan allelic discrimination. The regulation of HIF1a in the kidneys of diabetic mice was appreciated by immunohistochemistry, and the effectHIF1A Pro582Ser polymorphism on HIF-1a sensitivity to glucose was evaluated in vitro.
منابع مشابه
Impact of the Hypoxia-Inducible Factor-1 α (HIF1A) Pro582Ser Polymorphism on Diabetes Nephropathy
OBJECTIVE Hypoxia plays a major pathogenic role in diabetic nephropathy (DN). We have investigated in this study the effect of hypoxia-inducible factor 1 α subunit (HIF1A) genetic polymorphisms on the development of DN. RESEARCH DESIGN AND METHODS In 1,165 American type 1 diabetic patients with and without DN selected from the Genetics of Kidneys in Diabetes (GoKinD) study, the HIF1A genetic ...
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تاریخ انتشار 2012